Wastewater Microbiome Analysis for Population Alcohol Abuse

Author:

Wu Jiangping1,Chen Yan1,Zhao Jiawei1,Prosun Tanjila Alam1,O’Brien Jake William2,Coin Lachlan34,Hai Faisal I.1,Sanderson-Smith Martina5ORCID,Jiang Guangming1

Affiliation:

1. School of Civil, Mining, Environmental and Architectural Engineering, University of Wollongong, Wollongong, NSW 2522, Australia

2. Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Brisbane, QLD 4102, Australia

3. Department of Clinical Pathology, The University of Melbourne, Parkville, MEL 3010, Australia

4. Department of Microbiology and Immunology, The University of Melbourne, Parkville, MEL 3010, Australia

5. School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia

Abstract

This study aims to unveil correlations between wastewater microbiota and the catchment-specific population health risk, specifically alcohol abuse, with smoking and obesity as confounding factors. Our study highlights the importance of extracting human-associated microbial communities from wastewater metagenomes by excluding environmental microorganisms, due to their irrelevance to human health. After excluding environmental microbes, we observed strong associations of all three health risk factors, including alcohol abuse, smoking and obesity, with the human gut microbiome in wastewater. The linear discriminant analysis effect size (LEfSe) analysis showed Lactococcus_A, Leuconostoc, Aeromicrobium, Akkermansia, Weissella, Limosilactobacillus, Klebsiella_A, Desulfovibrio and Cloacibacillus as potential microbial biomarkers for alcoholism, after accounting for the confounding effects of smoking and obesity. Functional annotations of microorganisms linked with lower alcoholism rates are primarily related to energy metabolism and intercellular communication. Microorganisms associated with higher alcoholism rates are predominantly involved in immune regulation and cellular DNA architecture. This study highlights the need for a comprehensive exploration of different health risk factors together to identify potential associations between the wastewater microbiome and population lifestyle.

Funder

Australian Research Council Discovery Project

Publisher

MDPI AG

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