Effect of Flow Velocity on Laminar Flow in Microfluidic Chips

Author:

Wu Chuang123ORCID,Almuaalemi Haithm Yahya Mohammed1ORCID,Sohan A. S. M. Muhtasim Fuad4ORCID,Yin Binfeng1ORCID

Affiliation:

1. School of Mechanical Engineering, Yangzhou University, Yangzhou 225127, China

2. Nantong Fuleda Vehicle Accessory Component Co., Ltd., Nantong 226300, China

3. Jiangsu Tongshun Power Technology Co., Ltd., Nantong 226300, China

4. Faculty of Engineering, Department of Mechanical Engineering, University of Adelaide, Adelaide, SA 5000, Australia

Abstract

Gel fibers prepared based on microfluidic laminar flow technology have important research value in constructing biomimetic scaffolds and tissue engineering. The key point of microfluidic laminar flow technology is to find the appropriate fluid flow rate in the micropipe. In order to explore the influence of flow rate on the laminar flow phenomenon of a microfluidic chip, a microfluidic chip composed of an intermediate main pipe and three surrounding outer pipes are designed, and the chip is prepared by photolithography and the composite molding method. Then, a syringe pump is used to inject different fluids into the microtubing, and the data of fluid motion are obtained through fluid dynamics simulation and finite element analysis. Finally, a series of optimal adjustments are made for different fluid composition and flow rate combinations to achieve the fluid’s stable laminar flow state. It was determined that when the concentration of sodium alginate in the outer phase was 1 wt% and the concentration of CaCl2 in the inner phase was 0.1 wt%, the gel fiber prepared was in good shape, the flow rate was the most stable, and laminar flow was the most obvious when the flow rate of both was 1 mL/h. This study represents a preliminary achievement in exploring the laminar flow rate and fabricating gel fibers, thus offering significant reference value for investigating microfluidic laminar flow technology.

Funder

Yangzhou City and Yangzhou University, China

“Green Yang Golden Phoenix Project” in Yangzhou City

National Natural Science Foundation of China

Natural Science Foundation of the Jiangsu Higher Education Institutions of China

Jiangsu Agricultural Science and Technology Innovation Fund

Science and Technology Planning Project of Yangzhou City

Market Supervision Administration Science and Technology Fund of Jiangsu Province

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering

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