Exploring the Impact of Alginate—PVA Ratio and the Addition of Bioactive Substances on the Performance of Hybrid Hydrogel Membranes as Potential Wound Dressings

Author:

Stan Diana12ORCID,Codrici Elena3,Enciu Ana-Maria34ORCID,Olewnik-Kruszkowska Ewa5ORCID,Gavril Georgiana6ORCID,Ruta Lavinia Liliana1ORCID,Moldovan Carmen7,Brincoveanu Oana78,Bocancia-Mateescu Lorena-Andreea1,Mirica Andreea-Cristina1,Stan Dana1,Tanase Cristiana39

Affiliation:

1. DDS Diagnostic, 031427 Bucharest, Romania

2. Doctoral School of Medicine, Titu Maiorescu University, 040441 Bucharest, Romania

3. Victor Babes National Institute of Pathology, 050096 Bucharest, Romania

4. Department of Cell Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania

5. Department of Physical Chemistry and Physicochemistry of Polymers, Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Toruń, Poland

6. Department of Bioinformatics, National Institute of Research and Development for Biological Sciences, 060031 Bucharest, Romania

7. National Institute for R&D in Microtechnology, 077190 Bucharest, Romania

8. Research Institute of the University of Bucharest, 060102 Bucharest, Romania

9. Department of Cell Biology and Clinical Biochemistry, Faculty of Medicine, Titu Maiorescu University, 040441 Bucharest, Romania

Abstract

Healthcare professionals face an ongoing challenge in managing both acute and chronic wounds, given the potential impact on patients’ quality of life and the limited availability of expensive treatment options. Hydrogel wound dressings offer a promising solution for effective wound care due to their affordability, ease of use, and ability to incorporate bioactive substances that enhance the wound healing process. Our study aimed to develop and evaluate hybrid hydrogel membranes enriched with bioactive components such as collagen and hyaluronic acid. We utilized both natural and synthetic polymers and employed a scalable, non-toxic, and environmentally friendly production process. We conducted extensive testing, including an in vitro assessment of moisture content, moisture uptake, swelling rate, gel fraction, biodegradation, water vapor transmission rate, protein denaturation, and protein adsorption. We evaluated the biocompatibility of the hydrogel membranes through cellular assays and performed instrumental tests using scanning electron microscopy and rheological analysis. Our findings demonstrate that the biohybrid hydrogel membranes exhibit cumulative properties with a favorable swelling ratio, optimal permeation properties, and good biocompatibility, all achieved with minimal concentrations of bioactive agents.

Funder

DDS Diagnostic company

Publisher

MDPI AG

Subject

Polymers and Plastics,Organic Chemistry,Biomaterials,Bioengineering

Reference178 articles.

1. Health-Related Quality of Life and Chronic Wound Characteristics among Patients with Chronic Wounds Treated in Primary Care: A Cross-Sectional Study in Singapore;Zhu;Int. Wound J.,2022

2. Human Wound and Its Burden: Updated 2020 Compendium of Estimates;Sen;Adv. Wound Care,2021

3. Wound Dressing Products: A Translational Investigation from the Bench to the Market;Laurano;Eng. Regen.,2022

4. Choosing a Wound Dressing Based on Common Wound Characteristics;Dabiri;Adv. Wound Care,2016

5. Selection of Appropriate Wound Dressing for Various Wounds;Shi;Front. Bioeng. Biotechnol.,2020

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3