Impact of Maternal Lifestyle and Dietary Habits during Pregnancy on Newborn Metabolic Profile
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Published:2023-05-13
Issue:10
Volume:15
Page:2297
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ISSN:2072-6643
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Container-title:Nutrients
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language:en
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Short-container-title:Nutrients
Author:
Cicalini Ilaria12ORCID, Moffa Samanta3, Tommolini Maria Lucia12, Valentinuzzi Silvia13, Zucchelli Mirco12ORCID, Bucci Ines14, Chiacchiaretta Piero12, Fontana Antonella3ORCID, Federici Luca12, De Laurenzi Vincenzo12, Del Boccio Piero13ORCID, Rossi Claudia12ORCID, Pieragostino Damiana12ORCID
Affiliation:
1. Center for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy 2. Department of Innovative Technologies in Medicine and Dentistry, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy 3. Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy 4. Department of Medicine and Aging Science, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Abstract
Expanded newborn screening (NBS) is a preventive program that allows for the early identification of over 40 congenital endocrine-metabolic diseases by analyzing dried blood spot samples collected from the newborn’s heel within 48–72 h of birth. The determination of amino acids and acyl-carnitines by Flow Injection Analysis Tandem Mass Spectrometry (FIA-MS/MS) may also highlight metabolic alterations resulting from external factors, such as maternal nutrition. In the present study, we developed a questionnaire to investigate the eating habits of 109 women during pregnancy and statistically correlated the results from the investigation on dietary habits with the data obtained by the NBS laboratory of Abruzzo region (Italy). Parameters such as smoking, physical activity, and the intake of iodized salt, drugs, and supplements were analyzed. This study aimed to highlight how maternal lifestyle, diet, and drug intake during pregnancy may affect the neonatal metabolic profile, possibly generating false positive or false negative results in the NBS test. The results pointed out how the knowledge of maternal nutrition and lifestyle may also be precious in preventing misinterpretations of the neonatal metabolic profile, thereby reducing unnecessary stress for newborns and their parents and limiting costs for the health system.
Subject
Food Science,Nutrition and Dietetics
Reference27 articles.
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