Abstract
Epigenetic modifications are crucial for chromatin remodeling and transcriptional regulation. Post-translational modifications of histones are epigenetic processes that are fine-tuned by writer and eraser enzymes, and the disorganization of these enzymes alters the cellular state, resulting in human diseases. The KDM5 family is an enzymatic family that removes di- and tri-methyl groups (me2 and me3) from lysine 4 of histone H3 (H3K4), and its dysregulation has been implicated in cancer. Although H3K4me3 is an active chromatin marker, KDM5 proteins serve as not only transcriptional repressors but also transcriptional activators in a demethylase-dependent or -independent manner in different contexts. Notably, KDM5 proteins regulate the H3K4 methylation cycle required for active transcription. Here, we review the recent findings regarding the mechanisms of transcriptional regulation mediated by KDM5 in various contexts, with a focus on cancer, and further shed light on the potential of targeting KDM5 for cancer therapy.
Funder
Japan Society for the Promotion of Science
Mochida Memorial Foundation for Medical and Pharmaceutical Research
Shinnihon Foundation of Advanced Medical Treatment Research
Princess Takamatsu Cancer Research Fund
Kobayashi Foundation for Cancer Research
Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
Japanese Society of Myeloma Research Award
Cited by
13 articles.
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