The Role of Mammalian STK38 in DNA Damage Response and Targeting for Radio-Sensitization-Reference-Cited by-同舟云学术

The Role of Mammalian STK38 in DNA Damage Response and Targeting for Radio-Sensitization

Published:2023-03-30 Issue:7 Volume:15 Page:2054
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Fukasawa Takemichi¹^ORCID,Enomoto Atsushi²,Yoshizaki-Ogawa Asako¹,Sato Shinichi¹,Miyagawa Kiyoshi²,Yoshizaki Ayumi¹^ORCID

Affiliation:

1. Department of Dermatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

2. Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Abstract

Protein kinases, found in the nucleus and cytoplasm, play essential roles in a multitude of cellular processes, including cell division, proliferation, apoptosis, and signal transduction. STK38 is a member of the protein kinase A (PKA)/PKG/PKC family implicated in regulating cell division and morphogenesis in yeast and C. elegans. However, its function remained largely unknown in mammals. In recent years, advances in research on STK38 and the identification of its substrates has led to a better understanding of its function and role in mammals. This review discusses the structure, expression, and regulation of activity as a kinase, its role in the DNA damage response, cross-talk with other signaling pathways, and its application for radio-sensitization.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/7/2054/pdf

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