Therapy of Locally Advanced and Oligometastatic Pancreatic Adenocarcinoma-Reference-Cited by-同舟云学术

Therapy of Locally Advanced and Oligometastatic Pancreatic Adenocarcinoma

Published:2023-12-18 Issue:24 Volume:15 Page:5881
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Wahler Isabell Luisa¹,Damanakis Alexander¹,Große Hokamp Nils²^ORCID,Bruns Christiane¹,Schmidt Thomas¹^ORCID

Affiliation:

1. Department of General, Visceral, Cancer and Transplant Surgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany

2. Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Hospital of Cologne, 50923 Cologne, Germany

Abstract

Pancreatic adenocarcinoma is a lethal disease, and surgical resection remains the only curative treatment option. Unfortunately, upon primary diagnosis, only 15–20% of all patients with pancreatic ductal adenocarcinoma (PDAC) have localized disease that is eligible for operation. The remainder of patients either have borderline resectable or locally advanced disease or present with distant metastasis. In this review, we present a comprehensive overview regarding the current strategies and future directions in the multimodal therapy of locally advanced and oligometastasized pancreatic adenocarcinoma and discuss the benefit of surgery following neoadjuvant therapy in these patients.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/24/5881/pdf

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