Malignant Brenner Tumor of the Ovary: A Systematic Review of the Literature

Author:

Koufopoulos Nektarios I.1ORCID,Pouliakis Abraham1ORCID,Samaras Menelaos G.1,Kotanidis Christakis1,Boutas Ioannis2ORCID,Kontogeorgi Adamantia3,Dimas Dionysios4,Sitara Kyparissia5,Zacharatou Andriani1ORCID,Ieronimaki Argyro-Ioanna1,Spathis Aris1ORCID,Leventakou Danai1ORCID,Zanelli Magda6ORCID,Pateras Ioannis S.1,Panayiotides Ioannis G.1,Palicelli Andrea6ORCID,Syrios John7ORCID

Affiliation:

1. Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece

2. Breast Unit, Rea Maternity Hospital, 17564 Athens, Greece

3. 3rd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece

4. Breast Unit, Athens Medical Center, Psychiko Clinic, 11525 Athens, Greece

5. Department of Internal Medicine, “Elpis” General Hospital of Athens, 11522 Athens, Greece

6. Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy

7. Second Department of Medical Oncology, Mitera Hospital, 15123 Athens, Greece

Abstract

Background: Malignant Brenner tumors are rare ovarian tumors, accounting for less than 1% of malignant ovarian neoplasms. The aim of this manuscript is to systematically review the current literature concerning malignant Brenner tumors. Methods: We searched three medical databases (PubMed, Scopus, and Web of Science) for relevant articles published until 15 September 2023. Results: After applying inclusion and exclusion criteria, 48 manuscripts describing 115 cases were included in this study from the English literature. Conclusions: We analyzed the demographic, clinical, pathological, and oncological characteristics of 115 patients with malignant Brenner tumors. The statistical analysis showed that recurrence was marginally statistically significantly related to tumor stage and was more common in patients with ascites and in women with abnormal CA-125 levels; patients that were treated with lymphadenectomy had better disease-specific survival.

Funder

Italian Ministry of Health—Ricerca Corrente Annual Program 2025

Publisher

MDPI AG

Reference69 articles.

1. WHO Classification of Tumours Editorial Board (2020). Female Genital Tumours, International Agency for Research on Cancer. [5th ed.].

2. Features of ovarian Brenner tumors: Experience of a single tertiary center;Turgay;Turk. J. Obstet. Gynecol.,2017

3. Ovarian Brenner tumour: A morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium;Kuhn;Eur. J. Cancer,2013

4. Das oophoroma folliculare;Brenner;Frankf. Z. Pathol.,1907

5. Obstetrical-gynecological eponyms: Fritz Brenner and Brenner tumors of the ovary;Speert;Cancer,1956

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