Author:
Zhai Fengguang,Wang Jie,Yang Weili,Ye Meng,Jin Xiaofeng
Abstract
Endometrial (EC) and cervical (CC) cancers are the most prevalent malignancies of the female reproductive system. There is a global trend towards increasing incidence and mortality, with a decreasing age trend. E3 ligases label substrates with ubiquitin to regulate their activity and stability and are involved in various cellular functions. Studies have confirmed abnormal expression or mutations of E3 ligases in EC and CC, indicating their vital roles in the occurrence and progression of EC and CC. This paper provides an overview of the E3 ligases implicated in EC and CC and discusses their underlying mechanism. In addition, this review provides research advances in the target of ubiquitination processes in EC and CC.
Funder
The Medical and health science and Technology project of Zhejiang Province
The National Natural Science Foundation of China
The Natural Science Foundation of Ningbo
The Fundamental Research Funds for the Provincial Universities of Zhejiang
The K.C. Wong Magna Fund in Ningbo University
Cited by
12 articles.
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