The Evolving Role of Stereotactic Body Radiation Therapy for Head and Neck Cancer: Where Do We Stand?-Reference-Cited by-同舟云学术

The Evolving Role of Stereotactic Body Radiation Therapy for Head and Neck Cancer: Where Do We Stand?

Published:2023-10-16 Issue:20 Volume:15 Page:5010
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Mohamad Issa¹^ORCID,Karam Irene²,El-Sehemy Ahmed³,Abu-Gheida Ibrahim⁴⁵,Al-Ibraheem Akram⁶^ORCID,AL-Assaf Hossam⁷,Aldehaim Mohammed⁸,Alghamdi Majed⁹¹⁰,Alotain Ibrahim¹¹,Ashour May¹²,Bushehri Ahmad¹³,ElHaddad Mostafa¹⁴,Hosni Ali¹⁵

Affiliation:

1. Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan

2. Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, ON M4N3M5, Canada

3. Faculty of Medicine, University of Toronto, Toronto, ON M5S1A1, Canada

4. Department of Radiation Oncology, Burjeel Medical City, Abu Dhabi 7400, United Arab Emirates

5. Emirates Oncology Society, Dubai 2299, United Arab Emirates

6. Department of Nuclear Medicine, King Hussein Cancer Center, Amman 11941, Jordan

7. Department of Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 11525, Saudi Arabia

8. Department of Radiation Oncology, King Faisal Specialist Hospital and Research Center Riyadh, Riyadh 11211, Saudi Arabia

9. Radiation Oncology, Princess Noorah Oncology Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs-Western Region, Jeddah 21556, Saudi Arabia

10. College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah 11481, Saudi Arabia

11. Department of Radiation Oncology, King Fahad Specialist, Dammam 31444, Saudi Arabia

12. Department of Radiation Oncology, National Cancer Institute, Cairo University, Cairo 11796, Egypt

13. Department of Radiation Oncology, Kuwait Cancer Control Center, Kuwait 42262, Kuwait

14. Clinical Oncology Department, Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 12613, Egypt

15. Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON M5G2M9, Canada

Abstract

Stereotactic body radiation therapy (SBRT) is a precise and conformal radiation therapy (RT) that aims to deliver a high dose of radiation to the tumor whilst sparing surrounding normal tissue, making it an attractive option for head and neck cancer (HNC) patients who are not suitable for the traditional long course of RT with comprehensive RT target volume. Definitive SBRT for HNC has been investigated in different settings, including early stage glottis cancer, and as an alternative to brachytherapy boost after external beam RT. It is also used as a primary treatment option for elderly or medically unfit patients. More recently, an SBRT combination with immunotherapy in the neoadjuvant setting for HNC showed promising results. Salvage or adjuvant SBRT for HNC can be used in appropriately selected cases. Future studies are warranted to determine the optimum dose and fractionation schedules in any of these indications.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/20/5010/pdf

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