The CAM Model—Q&A with Experts

Author:

Fischer Dagmar,Fluegen GeorgORCID,Garcia Paul,Ghaffari-Tabrizi-Wizsy Nassim,Gribaldo LauraORCID,Huang Ruby Yun-JuORCID,Rasche VolkerORCID,Ribatti Domenico,Rousset XavierORCID,Pinto Marta TexeiraORCID,Viallet Jean,Wang Yan,Schneider-Stock Regine

Abstract

The chick chorioallantoic membrane (CAM), as an extraembryonic tissue layer generated by the fusion of the chorion with the vascularized allantoic membrane, is easily accessible for manipulation. Indeed, grafting tumor cells on the CAM lets xenografts/ovografts develop in a few days for further investigations. Thus, the CAM model represents an alternative test system that is a simple, fast, and low-cost tool to study tumor growth, drug response, or angiogenesis in vivo. Recently, a new era for the CAM model in immune-oncology-based drug discovery has been opened up. Although there are many advantages offering extraordinary and unique applications in cancer research, it has also disadvantages and limitations. This review will discuss the pros and cons with experts in the field.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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