Current Status of Targeted Therapy for Biliary Tract Cancer in the Era of Precision Medicine

Author:

Mie Takafumi1ORCID,Sasaki Takashi1ORCID,Okamoto Takeshi1ORCID,Furukawa Takaaki1,Takeda Tsuyoshi1ORCID,Kasuga Akiyoshi1ORCID,Ozaka Masato1,Sasahira Naoki1

Affiliation:

1. Department of Hepato-Biliary-Pancreatic Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan

Abstract

First-line chemotherapy has been established for advanced biliary tract cancer (BTC). However, few treatment options are available as second-line treatment. Advances in comprehensive genomic analysis revealed that nearly half of patients with BTC harbor targetable genetic alterations such as fibroblast growth factor receptor (FGFR), isocitrate dehydrogenase (IDH), BRAF, human epidermal growth factor receptor 2 (HER2), microsatellite instability (MSI)-high, neurotrophic tropomyosin receptor kinase (NTRK), rearranged during transfection (RET), and poly (adenosine diphosphate-ribose) polymerase (PARP). This review summarizes currently available options in precision medicine and clinical trials for patients with advanced BTC.

Publisher

MDPI AG

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