Magnetic Resonance Imaging Features Associated with a High and Low Expression of Tumor-Infiltrating Lymphocytes: A Stratified Analysis According to Molecular Subtypes

Author:

Zhou Jiejie12,Jin Yi3,Miao Haiwei1,Lu Shanshan3,Liu Xinmiao1,He Yun1,Liu Huiru1,Zhao Youfan1,Zhang Yang2,Liu Yan-Lin2ORCID,Pan Zhifang4,Chen Jeon-Hor2,Wang Meihao1,Su Min-Ying25ORCID

Affiliation:

1. Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

2. Department of Radiological Sciences, University of California, Irvine, CA 92697, USA

3. Department of Pathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

4. Zhejiang Engineering Research Center of Intelligent Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

5. Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 840203, Taiwan

Abstract

A total of 457 patients, including 241 HR+/HER2− patients, 134 HER2+ patients, and 82 TN patients, were studied. The percentage of TILs in the stroma adjacent to the tumor cells was assessed using a 10% cutoff. The low TIL percentages were 82% in the HR+ patients, 63% in the HER2+ patients, and 56% in the TN patients (p < 0.001). MRI features such as morphology as mass or non-mass enhancement (NME), shape, margin, internal enhancement, presence of peritumoral edema, and the DCE kinetic pattern were assessed. Tumor sizes were smaller in the HR+/HER2− group (p < 0.001); HER2+ was more likely to present as NME (p = 0.031); homogeneous enhancement was mostly seen in HR+ (p < 0.001); and the peritumoral edema was present in 45% HR+, 71% HER2+, and 80% TN (p < 0.001). In each subtype, the MR features between the high- vs. low-TIL groups were compared. In HR+/HER2−, peritumoral edema was more likely to be present in those with high TILs (70%) than in those with low TILs (40%, p < 0.001). In TN, those with high TILs were more likely to present a regular shape (33%) than those with low TILs (13%, p = 0.029) and more likely to present the circumscribed margin (19%) than those with low TILs (2%, p = 0.009).

Funder

First Affiliated Hospital of Wenzhou Medical University

Wenzhou Science & Technology Bureau

Zhejiang Provincial Natural Science Foundation of China

Key Laboratory of Intelligent Medical Imaging of Wenzhou

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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