Novel Immunotherapeutic Approaches to Treating HPV-Related Head and Neck Cancer

Author:

Saba Nabil F.1ORCID,Pamulapati Saagar2ORCID,Patel Bhamini3,Mody Mayur4,Strojan Primož5ORCID,Takes Robert6,Mäkitie Antti A.7ORCID,Cohen Oded8,Pace-Asciak Pia9,Vermorken Jan B.1011ORCID,Bradford Carol12,Forastiere Arlene13,Teng Yong1ORCID,Wieland Andreas121415ORCID,Ferlito Alfio16ORCID

Affiliation:

1. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA

2. Internal Medicine Program, Mercyhealth, Rockford, IL 61114, USA

3. Department of Internal Medicine, Emory University, Atlanta, GA 30307, USA

4. Hematology and Oncology Program, AdventHealth Medical Group, Calhoun, GA 30701, USA

5. Department of Radiation Oncology, Institute of Oncology, 1000 Ljubljana, Slovenia

6. Department of Otolaryngology and Head and Neck Surgery, Radboud University Medical Center, 6525 Nijmegen, The Netherlands

7. Department of Otorhinolaryngology—Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, Research Program in Systems Oncology, FI-00014 Helsinki, Finland

8. Department of Otolaryngology, Ben Gurion University of the Negev, Soroka Medical Center, Be’er Sheva 84-101, Israel

9. Department of Otolarynology—Head and Neck Surgery, University of Toronto, Toronto, ON M5S 1A1, Canada

10. Department of Medical Oncology, Antwerp University Hospital, 2650 Edegem, Belgium

11. Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium

12. Department of Otolaryngology, The Ohio State University, Columbus, OH 43212, USA

13. Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA

14. Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA

15. Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA

16. Coordinator of the International Head and Neck Scientific Group, 35100 Padua, Italy

Abstract

Head and neck cancer (HNC) is the seventh most common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) accounting for a majority of cases in the western world. While HNC accounts for only 5% of all cancers in the United States, the incidence of a subset of OPSCC caused by human papillomavirus (HPV) is increasing rapidly. The treatment for OPSCC is multifaceted, with a recently emerging focus on immunotherapeutic approaches. With the increased incidence of HPV-related OPSCC and the approval of immunotherapy in the management of recurrent and metastatic HNC, there has been rising interest in exploring the role of immunotherapy in the treatment of HPV-related OPSCC specifically. The immune microenvironment in HPV-related disease is distinct from that in HPV-negative OPSCC, which has prompted further research into various immunotherapeutics. This review focuses on HPV-related OPSCC, its immune characteristics, and current challenges and future opportunities for immunotherapeutic applications in this virus-driven cancer.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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