Performance of Comprehensive Complication Index and Clavien-Dindo Complication Scoring System in Liver Surgery for Hepatocellular Carcinoma
Author:
Giani AlessandroORCID, Cipriani Federica, Famularo SimoneORCID, Donadon MatteoORCID, Bernasconi Davide Paolo, Ardito FrancescoORCID, Fazio FedericoORCID, Nicolini DanieleORCID, Perri Pasquale, Giuffrida MarioORCID, Pontarolo Nicholas, Zanello Matteo, Lai QuirinoORCID, Conci Simone, Molfino SarahORCID, Germani PaolaORCID, Pinotti Enrico, Romano Maurizio, La Barba GiulianoORCID, Ferrari CeciliaORCID, Patauner Stefan, Manzoni Alberto, Sciannamea Ivano, Fumagalli Luca, Troci AlbertORCID, Ferraro Valentina, Floridi Antonio, Romano Fabrizio, Ciulli Cristina, Braga Marco, Ratti Francesca, Costa Guido, Razionale Francesco, Russolillo Nadia, Marinelli LauraORCID, De Peppo ValerioORCID, Cremaschi Elena, Calabrese FrancescoORCID, Larghi Laureiro Zoe, Lazzari Giovanni, Cosola Davide, Montuori MauroORCID, Salvador Luca, Cucchetti Alessandro, Franceschi Angelo, Ciola Michele, Sega Valentina, Calcagno Pietro, Pennacchi LucaORCID, Tedeschi Michele, Memeo Riccardo, Crespi Michele, Chiarelli Marco, Antonucci Adelmo, Zimmitti Giuseppe, Frena AntonioORCID, Percivale Andrea, Ercolani Giorgio, Zanus Giacomo, Zago MauroORCID, Tarchi PaolaORCID, Baiocchi Gian Luca, Ruzzenente Andrea, Rossi Massimo, Jovine Elio, Maestri MarcelloORCID, Dalla Valle Raffaele, Grazi Gian LucaORCID, Vivarelli Marco, Ferrero Alessandro, Giuliante Felice, Torzilli Guido, Aldrighetti Luca, Gianotti LucaORCID
Abstract
Background: We aimed to assess the ability of comprehensive complication index (CCI) and Clavien-Dindo complication (CDC) scale to predict excessive length of hospital stay (e-LOS) in patients undergoing liver resection for hepatocellular carcinoma. Methods: Patients were identified from an Italian multi-institutional database and randomly selected to be included in either a derivation or validation set. Multivariate logistic regression models and ROC curve analysis including either CCI or CDC as predictors of e-LOS were fitted to compare predictive performance. E-LOS was defined as a LOS longer than the 75th percentile among patients with at least one complication. Results: A total of 2669 patients were analyzed (1345 for derivation and 1324 for validation). The odds ratio (OR) was 5.590 (95%CI 4.201; 7.438) for CCI and 5.507 (4.152; 7.304) for CDC. The AUC was 0.964 for CCI and 0.893 for CDC in the derivation set and 0.962 vs. 0.890 in the validation set, respectively. In patients with at least two complications, the OR was 2.793 (1.896; 4.115) for CCI and 2.439 (1.666; 3.570) for CDC with an AUC of 0.850 and 0.673, respectively in the derivation cohort. The AUC was 0.806 for CCI and 0.658 for CDC in the validation set. Conclusions: When reporting postoperative morbidity in liver surgery, CCI is a preferable scale.
Subject
Cancer Research,Oncology
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|