Molecular Tailored Therapeutic Options for Advanced Gastrointestinal Stromal Tumors (GISTs): Current Practice and Future Perspectives-Reference-Cited by-同舟云学术

Molecular Tailored Therapeutic Options for Advanced Gastrointestinal Stromal Tumors (GISTs): Current Practice and Future Perspectives

Published:2023-03-30 Issue:7 Volume:15 Page:2074
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Catalano Fabio¹^ORCID,Cremante Malvina¹^ORCID,Dalmasso Bruna²^ORCID,Pirrone Chiara¹,Lagodin D’Amato Agostina¹,Grassi Massimiliano¹,Comandini Danila¹

Affiliation:

1. Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy

2. Genetica dei Tumori Rari, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy

Abstract

Gastrointestinal stromal tumors (GISTs) are one of the most common mesenchymal tumors characterized by different molecular alterations that lead to specific clinical presentations and behaviors. In the last twenty years, thanks to the discovery of these mutations, several new treatment options have emerged. This review provides an extensive overview of GISTs’ molecular pathways and their respective tailored therapeutic strategies. Furthermore, current treatment strategies under investigation and future perspectives are analyzed and discussed.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/7/2074/pdf

Reference138 articles.

1. Diagnosis and management of gastrointestinal stromal tumors: An up-to-date literature review;Mekkodathil;J. Cancer Res. Ther.,2017

2. Epidemiology of Gastrointestinal Stromal Tumors in the Era of Histology Codes: Results of a Population-Based Study;Ma;Cancer Epidemiol. Biomark. Prev.,2015

3. Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies;Sandvik;Cancer Epidemiol.,2016

4. Natural history of imatinib-naive GISTs: A retrospective analysis of 929 cases with long-term follow-up and development of a survival nomogram based on mitotic index and size as continuous variables;Rossi;Am. J. Surg. Pathol.,2011

5. Clinical and molecular genetics of patients with the Carney–Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD;Pasini;Eur. J. Hum. Genet.,2008

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Hereditary succinate dehydrogenase-deficient renal cell carcinoma;Seminars in Diagnostic Pathology;2024-01