Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset

Author:

Himbert CarolineORCID,Figueiredo Jane C.,Shibata David,Ose JenniferORCID,Lin Tengda,Huang Lyen C.ORCID,Peoples Anita R.ORCID,Scaife Courtney L.,Pickron Bartley,Lambert Laura,Cohan Jessica N.ORCID,Bronner Mary,Felder Seth,Sanchez Julian,Dessureault Sophie,Coppola Domenico,Hoffman David M.,Nasseri Yosef F.,Decker Robert W.,Zaghiyan Karen,Murrell Zuri A.,Hendifar Andrew,Gong Jun,Firoozmand Eiman,Gangi Alexandra,Moore Beth A.,Cologne Kyle G.,El-Masry Maryliza S.,Hinkle Nathan,Monroe Justin,Mutch Matthew,Bernadt Cory,Chatterjee Deyali,Sinanan Mika,Cohen Stacey A.,Wallin Ulrike,Grady William M.,Lampe Paul D.ORCID,Reddi Deepti,Krane Mukta,Fichera AlessandroORCID,Moonka Ravi,Herpel Esther,Schirmacher Peter,Kloor Matthias,von Knebel-Doeberitz Magnus,Nattenmueller Johanna,Kauczor Hans-Ulrich,Swanson Eric,Jedrzkiewicz Jolanta,Schmit Stephanie L.,Gigic BiljanaORCID,Ulrich Alexis B.ORCID,Toriola Adetunji T.,Siegel Erin M.ORCID,Li Christopher I.,Ulrich Cornelia M.ORCID,Hardikar SheetalORCID

Abstract

Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (<50 years) vs. late-onset (≥50 years) disease in a large multinational cohort of colorectal cancer patients (n = 2193). We calculated descriptive statistics and assessed associations of clinicodemographic factors with age of onset using mutually-adjusted logistic regression models. Patients were on average 60 years old, with BMI of 29 kg/m2, 52% colon cancers, 21% early-onset, and presented with stage II or III (60%) disease. Early-onset patients presented with more advanced disease (stages III–IV: 63% vs. 51%, respectively), and received more neo and adjuvant treatment compared to late-onset patients, after controlling for stage (odds ratio (OR) (95% confidence interval (CI)) = 2.30 (1.82–3.83) and 2.00 (1.43–2.81), respectively). Early-onset rectal cancer patients across all stages more commonly received neoadjuvant treatment, even when not indicated as the standard of care, e.g., during stage I disease. The odds of early-onset disease were higher among never smokers and lower among overweight patients (1.55 (1.21–1.98) and 0.56 (0.41–0.76), respectively). Patients with early-onset colorectal cancer were more likely to be diagnosed with advanced stage disease, to have received systemic treatments regardless of stage at diagnosis, and were less likely to be ever smokers or overweight.

Funder

National Cancer Institute

Stiftung LebensBlicke

Matthias Lackas-Stiftung

Florida Department of Health

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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