Clinical and Biological Differences between Upper Tract Carcinoma and Bladder Urothelial Cancer, Including Implications for Clinical Practice

Author:

Lefort Félix1ORCID,Rhanine Yasmine1,Larroquette Mathieu12ORCID,Domblides Charlotte12ORCID,Heraudet Luc1,Sionneau Baptiste1,Lambert Simon1,Lasserre Matthieu1,Robert Grégoire23ORCID,Ravaud Alain12,Gross-Goupil Marine1

Affiliation:

1. Department of Medical Oncology, University Hospital of Bordeaux, 33000 Bordeaux, France

2. Faculty of Medicine, University of Bordeaux, 33000 Bordeaux, France

3. Department of Urology, University Hospital of Bordeaux, 33000 Bordeaux, France

Abstract

Upper tract urothelial carcinoma (UTUC) is a rare disease included, along with the much more frequent urothelial bladder cancer (BUC), in the family of urothelial carcinomas (UCs). However, while UTUCs and BUCs share several features, their epidemiological, clinical, pathological, and biological differences must be considered to establish an optimal therapeutic strategy. This review examines the clinical differences between UTUC and BUC, as well as the main results obtained by molecular screening of the two diseases. The findings of clinical trials, performed in peri-operative and metastatic settings and assessing systemic treatments in UC, are summarised. A comparison of the data obtained for UTUC and BUC suggests improved therapeutic approaches, both in regards to routine practice and future drug development.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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