Affiliation:
1. Department of Chemical Engineering, Indian Institute of Technology, Tirupati 517619, India
2. Department of Radiology, Stanford University, Stanford, CA 94305, USA
Abstract
Extracellular vesicles (EVs) are lipid bilayer-enclosed bodies secreted by all cell types. EVs carry bioactive materials, such as proteins, lipids, metabolites, and nucleic acids, to communicate and elicit functional alterations and phenotypic changes in the counterpart stromal cells. In cancer, cells secrete EVs to shape a tumor-promoting niche. Tumor-secreted EVs mediate communications with immune cells that determine the fate of anti-tumor therapeutic effectiveness. Surface engineering of EVs has emerged as a promising tool for the modulation of tumor microenvironments for cancer immunotherapy. Modification of EVs’ surface with various molecules, such as antibodies, peptides, and proteins, can enhance their targeting specificity, immunogenicity, biodistribution, and pharmacokinetics. The diverse approaches sought for engineering EV surfaces can be categorized as physical, chemical, and genetic engineering strategies. The choice of method depends on the specific application and desired outcome. Each has its advantages and disadvantages. This review lends a bird’s-eye view of the recent progress in these approaches with respect to their rational implications in the immunomodulation of tumor microenvironments (TME) from pro-tumorigenic to anti-tumorigenic ones. The strategies for modulating TME using targeted EVs, their advantages, current limitations, and future directions are discussed.
Reference168 articles.
1. Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake;Abels;Cell Mol. Neurobiol.,2016
2. The roles of extracellular vesicles in the immune system;Buzas;Nat. Rev. Immunol.,2023
3. Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies;Gomzikova;Front. Cell Dev. Biol.,2021
4. Biological properties of extracellular vesicles and their physiological functions;Siljander;J. Extracell. Vesicles,2015
5. The biology, function, and biomedical applications of exosomes;Kalluri;Science,2020
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