Abstract
In this review, we summarize up-to-date reports with five-year observation after colorectal endoscopic submucosal dissection (ESD). Five-year cause-specific survival rates ranged from 98.6 to 100%. The local recurrence rates ranged from 1.1 to 2.2% in complete resection and 7.5 to 25.0% in incomplete resection. Incomplete resection was a risk factor for local recurrence. In non-curative ESD, five-year cause-specific survival rates ranged from 93.8 to 100% with additional surgery, and 92.7 to 99.1% without surgery. The choice of additional surgery should be based on the individual patient’s age, concomitant diseases, wishes, life expectancy, and the risk of lymph node metastasis. The metachronous cancer rates ranged from 0.22 to 1.1%. Both local recurrence and metachronous tumors should be checked with a follow-up colonoscopy after ESD.
Funder
Japan Agency for Medical Research and Development
Grant-in-Aid for Scientific Research B
Daiichi-Sankyo
Otsuka Pharm. Co, Ltd.
MSD Co.
Tanabe Pharm. Co.
Takeda Pharm. Co.
AbbVie Inc.
Biofermin Pharm. Co.
EA Pharma Co., Ltd.
Janssen Pharm. K.K.
Otsuka Pharm Co.
Takeda Pharm Co.
Tsumura Co.
Viatris Co.
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