Therapeutic Targets in Diffuse Midline Gliomas—An Emerging Landscape

Author:

Hayden Elisha,Holliday HollyORCID,Lehmann Rebecca,Khan Aaminah,Tsoli MariaORCID,Rayner Benjamin S.ORCID,Ziegler David S.ORCID

Abstract

Diffuse midline gliomas (DMGs) are invariably fatal pediatric brain tumours that are inherently resistant to conventional therapy. In recent years our understanding of the underlying molecular mechanisms of DMG tumorigenicity has resulted in the identification of novel targets and the development of a range of potential therapies, with multiple agents now being progressed to clinical translation to test their therapeutic efficacy. Here, we provide an overview of the current therapies aimed at epigenetic and mutational drivers, cellular pathway aberrations and tumor microenvironment mechanisms in DMGs in order to aid therapy development and facilitate a holistic approach to patient treatment.

Funder

Cancer Australia

Cancer Institute of New South Wales

DIPG collaborative

The Cure Starts Now

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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