Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma-Reference-Cited by-同舟云学术

Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma

Published:2023-03-30 Issue:7 Volume:15 Page:2051
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Brandt Anna¹,Thiele Benjamin²^ORCID,Schultheiß Christoph³^ORCID,Daetwyler Eveline⁴,Binder Mascha³⁴^ORCID

Affiliation:

1. Department of Internal Medicine 5, Hematology and Oncology, University Hospital of Erlangen, 91054 Erlangen, Germany

2. Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany

3. Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Straße 40, 06120 Halle (Saale), Germany

4. Division of Medical Oncology, University Hospital Basel, 4031 Basel, Switzerland

Abstract

Tumors shed cell-free DNA (cfDNA) into the plasma. “Liquid biopsies” are a diagnostic test to analyze cfDNA in order to detect minimal residual cancer, profile the genomic tumor landscape, and monitor cancers non-invasively over time. This technique may be useful in patients with head and neck squamous cell carcinoma (HNSCC) due to genetic tumor heterogeneity and limitations in imaging sensitivity. However, there are technical challenges that need to be overcome for the widespread use of liquid biopsy in the clinical management of these patients. In this review, we discuss our current understanding of HNSCC genetics and the role of cfDNA genomic analyses as an emerging precision diagnostic tool.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/7/2051/pdf

Reference155 articles.

1. Head and Neck Cancer;Chow;N. Engl. J. Med.,2020

2. Head and neck squamous cell carcinoma;Johnson;Nat. Rev. Dis. Primers,2020

3. The molecular biology of head and neck cancer;Leemans;Nat. Rev. Cancer,2011

4. Head and neck cancer;Mody;Lancet,2021

5. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung;CA Cancer J. Clin.,2021

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