Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio: Side by Side with Molecular Mutations in Patients with Non-Small Cell Lung Cancer—The INOLUNG Study

Author:

Budin Corina Eugenia12ORCID,Cocuz Iuliu Gabriel13ORCID,Enache Liviu Sorin45ORCID,Rența Ionuț Alexandru2,Cazacu Cristian6,Pătrîntașu Dariana Elena2,Olteanu Mihai78,Râjnoveanu Ruxandra-Mioara910ORCID,Ianoși Edith Simona11ORCID,Râjnoveanu Armand12ORCID,Cotoi Ovidiu Simion13

Affiliation:

1. Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania

2. Pneumology Department, Clinical County Hospital Mureș, 540136 Târgu Mureș, Romania

3. Pathology Department, Clinical County Hospital Mureș, 540136 Târgu Mureș, Romania

4. Emergency Clinical Hospital, 540136 Târgu Mureș, Romania

5. “Dimitrie Cantemir” University, 540545 Târgu Mureș, Romania

6. George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania

7. Pneumology Department, University of Medicine and Pharmacy, 700115 Craiova, Romania

8. Victor Babeș Hospital, 200515 Craiova, Romania

9. Palliative Medicine Department, Iuliu Hațieganu University of Medicine and Pharmacy Cluj Napoca, 400348 Cluj Napoca, Romania

10. Leon Daniello Hospital, 400332 Cluj Napoca, Romania

11. Pneumology Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania

12. Occupational Medicine Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400348 Cluj-Napoca, Romania

Abstract

Background and objective: Analysis of inflammatory biomarkers, along with the neutrophil/lymphocyte ratio (NLR) or platelet/lymphocyte ratio (PLR), supports the connection between inflammation and carcinogenesis. Methods: We conducted a retrospective observational study at the Clinical County Hospital Mureș involving patients with lung cancer. The parameters analyzed included histopathological type (NSCLC: squamous cell carcinoma or adenocarcinoma; SCLC), molecular mutations (EGFR, ALK, PD-L1), parameters from the complete blood count, inflammatory parameters, and associated comorbidities. Results: A total of 380 patients were included: 115 patients in the cancer group and 265 patients in the control group. Among patients in the lung cancer group, 88 were diagnosed with NSCLC (44 adenocarcinomas, 44 squamous cell carcinomas) and 27 with SCLC. Both NLR and PLR were significantly higher in cancer patients than in the control group (5.30 versus 2.60, p < 0.001; 217 versus 136, p < 0.001, respectively). NLR and PLR differ between men and women (p = 0.005 and p = 0.056, respectively). C-reactive protein was not correlated with either NLR (p-value: 0.0669) or PLR (p-value: 0.6733) in lung cancer patients. Conclusions: The NLR and PLR values may serve as new predictive biomarkers for the diagnosis of disease in patients with lung cancer, especially those with NSCLC.

Funder

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș

Publisher

MDPI AG

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