Analysis of the Peritumoral Tissue Unveils Cellular Changes Associated with a High Risk of Recurrence-Reference-Cited by-同舟云学术

Analysis of the Peritumoral Tissue Unveils Cellular Changes Associated with a High Risk of Recurrence

Published:2023-06-30 Issue:13 Volume:15 Page:3450
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Michot Audrey¹²³,Lagarde Pauline²³,Lesluyes Tom²,Darbo Elodie¹³^ORCID,Neuville Agnès²,Baud Jessica¹,Perot Gaëlle⁴⁵,Bonomo Iris²,Maire Mathilde²,Michot Maxime²,Coindre Jean-Michel²³,Le Loarer François¹²³,Chibon Frédéric⁴⁵^ORCID

Affiliation:

1. Bordeaux Institute of Oncology, BRIC U1312, INSERM, 33000 Bordeaux, France

2. Institut Bergonié, Centre de Lutte Contre le Cancer de Bordeaux, 33076 Bordeaux, France

3. Department of Biopathology, Bergonié Institute, Université Victor Segalen Site Carreire, Bordeaux 2, 33076 Bordeaux, France

4. OncoSarc, INSERM U1037, Cancer Research Center in Toulouse (CRCT), 31000 Toulouse, France

5. Department of Pathology, Institut Claudius Régaud, IUCT-Oncopole, 31000 Toulouse, France

Abstract

Background: The management of soft-tissue sarcoma (STS) relies on a multidisciplinary approach involving specialized oncological surgery combined with other adjuvant therapies to achieve optimal local disease control. Purpose and Results: Genomic and transcriptomic pseudocapsules of 20 prospective sarcomas were analyzed and revealed to be correlated with a higher risk of recurrence after surgery. Conclusions: A peritumoral environment that has been remodeled and infiltrated by M2 macrophages, and is less expressive of healthy tissue, would pose a significant risk of relapse and require more aggressive treatment strategies.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/13/3450/pdf

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