Current Challenges and Future Advances in Lung Cancer: Genetics, Instrumental Diagnosis and Treatment
Affiliation:
1. Thoracic Surgery Unit, Department of Translational Medicine, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy
Abstract
Lung cancer is a malignancy with a poor prognosis, with only 20% of patients having an overall survival longer than five years from diagnosis, and this prognosis has still not significantly improved despite developments in understanding the genetic evolution of lung cancer; improvements in the accuracy of diagnostic procedures; and refinements in the treatments with multimodal regimens, including surgery, radiotherapy and systemic therapy (chemotherapy, immunotherapy and targeted therapy) [...]
Subject
Cancer Research,Oncology
Reference10 articles.
1. Lázaro, S., Lorz, C., Enguita, A.B., Seller, I., Paramio, J.M., and Santos, M. (2022). Pten and p53 Loss in the Mouse Lung Causes Adenocarcinoma and Sarcomatoid Carcinoma. Cancers, 14. 2. Otake, S., Goto, T., Higuchi, R., Nakagomi, T., Hirotsu, Y., Amemiya, K., Oyama, T., Mochizuki, H., and Omata, M. (2022). The Diagnostic Utility of Cell-Free DNA from Ex Vivo Bronchoalveolar Lavage Fluid in Lung Cancer. Cancers, 14. 3. Kosibaty, Z., Brustugun, O.T., Eide, I.J.Z., Tsakonas, G., Grundberg, O., De Petris, L., McGowan, M., Hydbring, P., and Ekman, S. (2022). Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer. Cancers, 14. 4. Kuo, C., Tsai, M., Hung, J., Wu, K., Tsai, Y., Tsai, Y., Chuang, C., Lee, T., Chen, H., and Yang, C. (2023). Different Tyrosine Kinase Inhibitors Used in Treating EGFR-Mutant Pulmonary Adenocarcinoma with Brain Metastasis and Intracranial Intervention Have No Impact on Clinical Outcomes. Cancers, 15. 5. Rogado, J., Pozo, F., Troule, K., Sánchez-Torres, J.M., Romero-Laorden, N., Mondejar, R., Donnay, O., Ballesteros, A., Pacheco-Barcia, V., and Aspa, J. (2022). Peripheral Blood Mononuclear Cells Predict Therapeutic Efficacy of Immunotherapy in NSCLC. Cancers, 14.
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