High-Frequency Electroporation and Chemotherapy for the Treatment of Cutaneous Malignancies: Evaluation of Early Clinical Response

Author:

Lyons Phoebe1,Polini Dana2,Russell-Ryan Kate3,Clover A. James P.14ORCID

Affiliation:

1. Department of Plastic Surgery, Cork University Hospital, T12 DC4A Cork, Ireland

2. School of Medicine, University College Cork, T12 YN60 Cork, Ireland

3. Mirai Medical, H91 P5PH Oranmore, Ireland

4. Cancer Research@UCC, University College Cork, T12 YN60 Cork, Ireland

Abstract

High-frequency electroporation (HF-EP) with chemotherapy is a novel therapy proposed for both curative and palliative treatment of cutaneous malignancies. The use of high-frequency biphasic pulses is thought to reduce the painful muscle contractions associated with traditional electrochemotherapy (ECT), allowing treatment administration under local anaesthesia. This proof-of-concept study investigated the efficacy and tolerability of HF-EP protocols on a variety of cutaneous malignancies. A total of 97 lesions of five different histological subtypes were treated across 25 patients. At 12 weeks post-treatment, a 91.3% overall lesion response rate was observed (complete response: 79%; partial response: 12.3%), with excellent intraprocedural patient tolerability under local anaesthetic. HF-EP with chemotherapy shows promising results regarding tumour response rates for cutaneous malignancies of varying histological subtypes when compared to traditional ECT protocols. Improved patient tolerability is important, increasing the possibility of treatment delivery under local anaesthesia and potentially broadening the treatment envelope for patients with cutaneous malignancies.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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