Cyclophilin A: An Independent Prognostic Factor for Survival in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab and Chemotherapy

Author:

Moisuc Diana Cornelia1ORCID,Constantinescu Daniela12ORCID,Marinca Mihai Vasile34ORCID,Gafton Bogdan34,Pavel-Tanasa Mariana12ORCID,Cianga Petru12ORCID

Affiliation:

1. Immunology Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

2. Immunology Department, “St. Spiridon” Hospital, 700111 Iasi, Romania

3. Oncology Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

4. Oncology Department, Regional Institute of Oncology, 700483 Iasi, Romania

Abstract

Colorectal cancer (CRC) ranks as second most common cause of cancer-related deaths. The CRC management considerably improved in recent years, especially due to biological therapies such as bevacizumab. The lack of predictive or prognostic biomarkers remains one of the major disadvantages of using bevacizumab in the CRC management. We performed a prospective study to analyze the prognostic and predictive roles of three potential serum biomarkers (Cyclophilin A (CypA), copeptin and Tie2) investigated by ELISA in 56 patients with metastatic CRC undergoing bevacizumab and chemotherapy between May 2019 and September 2021 at baseline and after one and six months of therapy. We showed that low levels of CypA at baseline and after one month of treatment were associated with better overall survival (OS) (42 versus 24 months, p = 0.029 at baseline; 42 versus 25 months, p = 0.039 after one month). For copeptin and Tie2, Kaplan–Meier curves showed no correlation between these biomarkers and OS or progression-free survival. When adjusting for baseline and post-treatment factors, a multivariate Cox analysis showed that low values of CypA at baseline and after one month of treatment were independent prognostic factors for OS and correlated with a better prognosis in metastatic CRC patients.

Funder

Romanian Operational Program

“Multidisciplinary Medical Research-Development Platform in the NE region” CENEMED

Publisher

MDPI AG

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