Prevention and Treatment of HPV-Induced Skin Tumors

Author:

Hasche Daniel1ORCID,Akgül Baki2ORCID

Affiliation:

1. Division of Viral Transformation Mechanisms, Research Program “Infection, Inflammation and Cancer”, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany

2. Institute of Virology, Medical Faculty and University Hospital Cologne, University of Cologne, Fürst-Pückler-Str. 56, 50935 Cologne, Germany

Abstract

Non-melanoma skin cancer (NMSC) is the most common cancer in humans with increasing incidence. Meanwhile, a growing body of evidence has provided a link between skin infections with HPV of the genus beta (betaHPV) and the development of cutaneous squamous cell carcinomas (cSCCs). Based on this association, the development of vaccines against betaHPV has become an important research topic. This review summarizes the current advances in prophylactic and therapeutic betaHPV vaccines, including progresses made in preclinical testing and clinical trials.

Funder

the German Research Foundation

German Cancer Aid

Wilhelm Sander-Stiftung

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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