Radiation Therapy for Gestational Trophoblastic Neoplasia: Forward-Looking Lessons Learnt-Reference-Cited by-同舟云学术

Radiation Therapy for Gestational Trophoblastic Neoplasia: Forward-Looking Lessons Learnt

Published:2023-09-30 Issue:19 Volume:15 Page:4817
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Barcellini Amelia¹²^ORCID,Fodor Andrei³^ORCID,Charalampopoulou Alexandra⁴⁵^ORCID,Cassani Chiara⁶⁷^ORCID,Locati Laura Deborah²⁸,Cioffi Raffaella⁹^ORCID,Bergamini Alice⁹,Pignata Sandro¹⁰^ORCID,Orlandi Ester¹^ORCID,Mangili Giorgia⁹^ORCID

Affiliation:

1. Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy

2. Department of Internal Medicine and Medical Therapy, University of Pavia, 27100 Pavia, Italy

3. Department of Radiation Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

4. Radiobiology Unit, Research and Development Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy

5. Hadron Academy PhD Course, Istituto Universitario di STUDI Superiori (IUSS), 27100 Pavia, Italy

6. Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy

7. Unit of Obstetrics and Gynecology, IRCCS, Fondazione Policlinico San Matteo, 27100 Pavia, Italy

8. Translational Oncology Unit, Maugeri Clinical Research Institutes IRCCS, 27100 Pavia, Italy

9. Unit of Gynaecology and Obstetrics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

10. Department of Urology and Gynecology, Istituto Nazionale Tumori, IRCCS-Fondazione G. Pascale Napoli, 80131 Naples, Italy

Abstract

Gestational trophoblastic neoplasia (GTN) includes several rare malignant diseases occurring after pregnancy: invasive moles, choriocarcinoma, placental site trophoblastic tumours, and epithelioid trophoblastic tumours. Multidisciplinary protocols including multi-agent chemotherapy, surgery, and occasionally radiotherapy achieve good outcomes for some high-risk metastatic patients. In this narrative review of the published studies on the topic, we have tried to identify the role of radiotherapy. The available studies are mainly small, old, and retrospective, with incomplete data regarding radiotherapy protocols delivering low doses (which can make this disease appear radioresistant in some cases despite high response rates with palliative doses) to wide fields (whole-brain, whole-liver, etc.), which can increase toxicity. Studies considering modern techniques are needed to overcome these limitations and determine the full potential of radiotherapy beyond its antihemorrhagic and palliative roles.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/19/4817/pdf

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