The Use of San-Huang-Xie-Xin-Tang Reduces the Mortality Rate among Breast Cancer Patients

Author:

Winardi Daniel1,Wu Chieh-Hsin23,Chiang Jen-Huai4,Chen Yung-Hsiang15ORCID,Hsieh Ching-Liang67,Yang Juan-Cheng89,Wu Yang-Chang1810

Affiliation:

1. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan

2. Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan

3. Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan

4. Management Office for Health Data, Clinical Trial Research Center, China Medical University Hospital, Taichung 404, Taiwan

5. Department of Psychology, College of Medical and Health Science, Asia University, Taichung 413, Taiwan

6. Department of Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan

7. Graduate Institute of Integrated Medicine, Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan

8. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan

9. School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40604, Taiwan

10. Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung 413, Taiwan

Abstract

Globally, breast cancer is the most common cause of cancer deaths. In Taiwan, it is the most prevalent cancer among females. Since San-Huang-Xie-Xin-Tang (SHXXT) exerts not only an anti-inflammatory but an immunomodulatory effect, it may act as a potent anti-tumor agent. Herein, the study aimed to explore the influence of SHXXT and its constituents on the mortality rate among breast cancer patients in Taiwan regarding the component effect and the dose–relationship effect. By using the Taiwan National Health Insurance (NHI) Research Database (NHIRD), the study analyzed 5387 breast cancer patients taking Chinese herbal medicine (CHM) and 5387 breast cancer patients not using CHM. CHM means SHXXT and its constituents in the study. The Kaplan–Meier method was utilized to determine the mortality probabilities among patients. Whether the CHM influences the mortality rate among patients was estimated by Cox proportional hazard regression analysis. The use of CHM could lower the cancer mortality rate by 59% in breast cancer patients. The protective effect was parallel to the cumulative days of CHM use and the annual average CHM dose. In addition, the mortality rate was lower in patients who used SHXXT compared to those who only used one of its constituents. SHXXT and its constituents were all promising therapeutic weapons against breast cancer.

Funder

Ministry of Health and Welfare, Taiwan

China Medical University Hospital, Academia Sinica Stroke Biosignature Project

MOST Clinical Trial Consortium for Stroke

Tseng-Lien Lin Foundation

Taichung, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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