Radiation Safety Assessment in Prostate Cancer Treatment: A Predictive Approach for I-125 Brachytherapy-Reference-Cited by-同舟云学术

Radiation Safety Assessment in Prostate Cancer Treatment: A Predictive Approach for I-125 Brachytherapy

Published:2024-05-07 Issue:10 Volume:16 Page:1790
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Chuang Ho-Da¹²³,Lin Yu-Hung⁴,Lin Chin-Hsiung¹²³^ORCID,Lai Yuan-Chun⁵⁶^ORCID,Wu Chin-Hui⁷,Hsu Shih-Ming¹²

Affiliation:

1. Medical Physics and Radiation Measurements Laboratory, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan

2. Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan

3. Department of Medical Physics, Koo Foundation Sun Yat-sen Cancer Center, Taipei 11259, Taiwan

4. Department of Urology, Koo Foundation Sun Yat-sen Cancer Center, Taipei 11259, Taiwan

5. Department of Radiation Oncology, Changhua Christian Hospital, Changhua 50006, Taiwan

6. Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan

7. Department of Medical Imaging and Radiological Sciences, Tzu-Chi University of Science and Technology, Hualien 97005, Taiwan

Abstract

This study uses Monte Carlo simulation and experimental measurements to develop a predictive model for estimating the external dose rate associated with permanent radioactive source implantation in prostate cancer patients. The objective is to estimate the accuracy of the patient’s external dose rate measurement. First, I-125 radioactive sources were implanted into Mylar window water phantoms to simulate the permanent implantation of these sources in patients. Water phantom experimental measurement was combined with Monte Carlo simulation to develop predictive equations, whose performance was verified against external clinical data. The model’s accuracy in predicting the external dose rate in patients with permanently implanted I-125 radioactive sources was high (R2 = 0.999). A comparative analysis of the experimental measurements and the Monte Carlo simulations revealed that the maximum discrepancy between the measured and calculated values for the water phantom was less than 5.00%. The model is practical for radiation safety assessments, enabling the evaluation of radiation exposure risks to individuals around patients with permanently implanted I-125 radioactive sources.

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6694/16/10/1790/pdf

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