The Nervous System Development Regulator Neuropilin-1 as a Potential Prognostic Marker and Therapeutic Target in Brain Cancer-Reference-Cited by-同舟云学术

The Nervous System Development Regulator Neuropilin-1 as a Potential Prognostic Marker and Therapeutic Target in Brain Cancer

Published:2023-10-10 Issue:20 Volume:15 Page:4922
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Rodrigues Eduardo Mello¹²,Giovanini Allan Fernando¹,Ribas Carmen Australia Paredes Marcondes¹,Malafaia Osvaldo¹,Roesler Rafael³⁴⁵^ORCID,Isolan Gustavo R.¹²⁵⁶^ORCID

Affiliation:

1. Graduate Program in Principles of Surgery, Mackenzie Evangelical University, Curitiba 80730-000, PR, Brazil

2. The Center for Advanced Neurology and Neurosurgery (CEANNE), Porto Alegre 90560-010, RS, Brazil

3. Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil

4. Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil

5. National Science and Technology Institute for Children’s Cancer Biology and Pediatric Oncology—INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil

6. Spalt Therapeutics, Porto Alegre 90560-010, RS, Brazil

Abstract

Neuropilins are transmembrane glycoproteins that regulate developmental processes in the nervous system and other tissues. Overexpression of neuropilin-1 (NRP1) occurs in many solid tumor types and, in several instances, may predict patient outcome in terms of overall survival. Experimental inhibition of NRP1 activity can display antitumor effects in different cancer models. Here, we review NRP1 expression and function in adult and pediatric brain cancers, particularly glioblastomas (GBMs) and medulloblastomas, and present analyses of NRP1 transcript levels and their association with patient survival in GBMs. The case of NRP1 highlights the potential of regulators of neurodevelopment as biomarkers and therapeutic targets in brain cancer.

Funder

National Council for Scientific and Technological Development

Center for Advanced Neurology and Neurosurgery

Mackenzie Evangelical University

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/20/4922/pdf

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