Adipose Stem Cells and Their Interplay with Cancer Cells and Mitochondrial Reservoir: A New Promising Target-Reference-Cited by-同舟云学术

Adipose Stem Cells and Their Interplay with Cancer Cells and Mitochondrial Reservoir: A New Promising Target

Published:2024-08-05 Issue:15 Volume:16 Page:2769
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Rehman Ayesha¹^ORCID,Marigliano Martina²,Torsiello Martina¹,La Noce Marcella¹^ORCID,Papaccio Gianpaolo¹^ORCID,Tirino Virginia¹,Del Vecchio Vitale¹^ORCID,Papaccio Federica²^ORCID

Affiliation:

1. Department of Experimental Medicine, Section of Human Histology and Embryology, University of Campania “L. Vanvitelli”, Via L. Armanni 5, 80128 Naples, NA, Italy

2. Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Via S. Allende 43, 84081 Baronissi, SA, Italy

Abstract

Adipose-derived stem cells (ASCs) significantly influence tumor progression within the tumor microenvironment (TME). This review examines the pro-tumorigenic roles of ASCs, focusing on paracrine signaling, direct cell–cell interactions, and immunomodulation. ASC-mediated mitochondrial transfer through tunneling nanotubes (TNTs) and gap junctions (GJs) plays a significant role in enhancing cancer cell survival and metabolism. Cancer cells with dysfunctional mitochondria acquire mitochondria from ASCs to meet their metabolic needs and thrive in the TME. Targeting mitochondrial transfer, modulating ASC function, and influencing metabolic pathways are potential therapeutic strategies. However, challenges like TME complexity, specificity, safety concerns, and resistance mechanisms must be addressed. Disrupting the ASC–cancer cell–mitochondria axis offers a promising approach to cancer therapy.

Funder

Italian MUR PRIN 2020

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6694/16/15/2769/pdf

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