Outcomes and Techniques of Robotic-Assisted Partial Nephrectomy (RAPN) for Renal Hilar Masses: A Comprehensive Systematic Review

Author:

Pandolfo Savio Domenico123ORCID,Wu Zhenjie4,Campi Riccardo5ORCID,Bertolo Riccardo6ORCID,Amparore Daniele7ORCID,Mari Andrea5ORCID,Verze Paolo3,Manfredi Celeste89ORCID,Franco Antonio810,Ditonno Francesco68ORCID,Cerrato Clara11ORCID,Ferro Matteo12,Lasorsa Francesco13ORCID,Contieri Roberto14,Napolitano Luigi2ORCID,Tufano Antonio15,Lucarelli Giuseppe13ORCID,Cilio Simone2ORCID,Perdonà Sisto15,Siracusano Salvatore1,Autorino Riccardo8ORCID,Aveta Achille2ORCID

Affiliation:

1. Department of Urology, University of L’Aquila, 67010 L’Aquila, Italy

2. Department of Neurosciences and Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy

3. Department of Medicine and Surgery, Scuola Medica Salernitana, University of Salerno, 84081 Fisciano, Italy

4. Department of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China

5. Urological Robotic Surgery and Renal Transplantation Unit, Careggi Hospital, University of Florence, 50121 Firenze, Italy

6. Department of Urology, University of Verona, 37100 Verona, Italy

7. Division of Urology, Department of Oncology, School of Medicine, University of Turin, San Luigi Hospital, Orbassano, 10043 Turin, Italy

8. Department of Urology, Rush University Medical Center, Chicago, IL 60637, USA

9. Unit of Urology, Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy

10. Department of Urology, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, Italy

11. Urology Unit, University Hospital Southampton NHS Trust, Southampton SO16 6YD, UK

12. Division of Urology, IRCCS—European Institute of Oncology, 71013 Milan, Italy

13. Department of Precision and Regenerative Medicine and Ionian Area-Urology, Andrology and Kidney Transplantation Unit, University of Bari “Aldo Moro”, 70124 Bari, Italy

14. Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy

15. Department of Urology, Istituto Nazionale Tumori, IRCCS, “Fondazione G. Pascale”, 80131 Naples, Italy

Abstract

Background: Robot-assisted partial nephrectomy (RAPN) is increasingly being employed in the management of renal cell carcinoma (RCC) and it is expanding in the field of complex renal tumors. The aim of this systematic review was to consolidate and assess the results of RAPN when dealing with entirely central hilar masses and to examine the various methods used to address the surgical difficulties associated with them. Methods: A thorough literature search in September 2023 across various databases focused on RAPN for renal hilar masses, adhering to PRISMA guidelines. The primary goal was to evaluate RAPN’s surgical and functional outcomes, with a secondary aim of examining different surgical techniques. Out of 1250 records, 13 full-text manuscripts were reviewed. Results: Evidence is growing in favor of RAPN for renal hilar masses. Despite a predominance of retrospective studies and a lack of long-term data, RAPN shows positive surgical outcomes and preserves renal function without compromising cancer treatment effectiveness. Innovative suturing and clamping methods are emerging in surgical management. Conclusions: RAPN is a promising technique for managing renal hilar masses in RCC, offering effective surgical outcomes and renal function preservation. The study highlights the need for more long-term data and prospective studies to further validate these findings.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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