Kisspeptin and GPR54 Receptor Expression in Endometrial Cancer Tissue

Author:

Gowkielewicz Marek1ORCID,Lipka Aleksandra1ORCID,Piotrowska Aleksandra2ORCID,Szadurska-Noga Marta3,Nowakowski Jacek J.4ORCID,Lepiarczyk Ewa5ORCID,Wiszpolska Marta5,Waśniewski Tomasz1,Dzięgiel Piotr26ORCID,Kaleczyc Jerzy7ORCID,Majewski Mariusz Krzysztof5ORCID,Majewska Marta5ORCID

Affiliation:

1. Department of Gynecology and Obstetrics, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-045 Olsztyn, Poland

2. Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Chałubińskiego Street 6a, 50-368 Wroclaw, Poland

3. Department of Pathomorphology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland

4. Department of Ecology & Environmental Protection, University of Warmia and Mazury in Olsztyn, Plac Łódzki 3, 10-727 Olsztyn, Poland

5. Department of Human Physiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland

6. Division of Human Biology, Faculty of Physiotherapy, University School of Physical Education in Wroclaw, 51-612 Wroclaw, Poland

7. Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland

Abstract

Kisspeptin (KISS) is a natural peptide—discovered in 1996 as a factor inhibiting the ability to metastasize in malignant melanoma. This protein plays also a regulatory role in the process of puberty, the menstrual cycle, spermatogenesis, implantation and development of the human placenta. The present study aimed to evaluate the expression of KISS and its receptor GPR54 in endometrial cancer (EC) tissue, depending on the histological type of cancer, its stage, various demographic characteristics, and clinical conditions in 214 hysterectomy patients. Expression of KISS and GPR54 was confirmed in 99.5% and 100% of the cases, respectively. Hormone replacement therapy and the coexistence of the anti-Müllerian type 2 receptor in cancer tissue enhanced KISS expression. Smoking, on the other hand, decreased KISS expression. GPR54 expression increased with the advancement of the disease (according to FIGO classification). Also, the presence of the anti-Müllerian type 2 receptor in EC increased the level of GPR54. Hypertension, age and miscarriage harmed the presence of GPR54. The histological type of cancer, diabetes type 2, body mass index, hormonal contraception, number of deliveries, birth weight of newborns, breastfeeding time, and the presence of AMH in EC tissue were not associated with the expression of either KISS nor GPR54. The KISS level was also significantly related to the GPR54 level. Considering that KISS is a non-toxic peptide with antimetastatic properties, further investigation is essential to determine the clinical significance of this peptide.

Funder

National Science Centre

University of Warmia and Mazury

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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1. Kisspeptin Regulates Cell Invasion and Migration in Endometrial Cancer;Journal of the Endocrine Society;2024-01-08

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