Low-Dose Radiation Therapy (LDRT) against Cancer and Inflammatory or Degenerative Diseases: Three Parallel Stories with a Common Molecular Mechanism Involving the Nucleoshuttling of the ATM Protein?

Author:

Le Reun Eymeric1,Foray Nicolas1ORCID

Affiliation:

1. Inserm, U1296 Unit, “Radiation: Defense, Health and Environment”, Centre Léon-Bérard, 28 rue Laennec, 69008 Lyon, France

Abstract

Very early after their discovery, X-rays were used in multiple medical applications, such as treatments against cancer, inflammation and pain. Because of technological constraints, such applications involved X-ray doses lower than 1 Gy per session. Progressively, notably in oncology, the dose per session increased. However, the approach of delivering less than 1 Gy per session, now called low-dose radiation therapy (LDRT), was preserved and is still applied in very specific cases. More recently, LDRT has also been applied in some trials to protect against lung inflammation after COVID-19 infection or to treat degenerative syndromes such as Alzheimer’s disease. LDRT illustrates well the discontinuity of the dose-response curve and the counterintuitive observation that a low dose may produce a biological effect higher than a certain higher dose. Even if further investigations are needed to document and optimize LDRT, the apparent paradox of some radiobiological effects specific to low dose may be explained by the same mechanistic model based on the radiation-induced nucleoshuttling of the ATM kinase, a protein involved in various stress response pathways.

Funder

Commissariat General à l’Investissement

Centre National d’Etudes Spatiales

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Reference114 articles.

1. Radiation therapy of tuberculosis of hilar lymph nodes;Newmark;JAMA,1955

2. Observation concernant un cas de cancer de l’estomac traité par les rayons Roentgen;Despeignes;Lyon Méd.,1896

3. Observation concernant un cas de cancer de l’estomac traité par les rayons Roentgen;Despeignes;Lyon Méd.,1896

4. Radiation oncology: A century of achievements;Bernier;Nat. Rev. Cancer,2004

5. Über Heilung des Gelenkrheumatismus durch Röntgenstrahlen bei. Kindern;Fortschr. Dem Geb. Der Röntgenstrahlen,1898

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