Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers-Reference-Cited by-同舟云学术

Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers

Published:2024-01-14 Issue:2 Volume:16 Page:360
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Willbanks Amber¹,Seals Mina¹,Karmali Reem²³,Roy Ishan¹²³⁴^ORCID

Affiliation:

1. Shirley Ryan AbilityLab, Chicago, IL 60611, USA

2. Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

3. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA

4. Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL 60611, USA

Abstract

Options for treatment of incurable cancer remain scarce and are largely focused on limited therapeutic mechanisms. A new approach specific to advanced cancers is needed to identify new and effective treatments. Morbidity in advanced cancer is driven by functional decline and a number of systemic conditions, including cachexia and fatigue. This review will focus on these clinical concepts, describe our current understanding of their underlying biology, and then propose how future therapeutic strategies, including pharmaceuticals, exercise, and rehabilitation, could target these mechanisms as an alternative route to addressing incurable cancer.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/16/2/360/pdf

Reference197 articles.

1. Centers for Disease Control and Prevention (2021). Incidence and Relative Survival by Stage at Diagnosis for Common Cancers. USCS Data Brief., 25, Available online: https://www.cdc.gov/cancer/uscs/about/data-briefs/no25-incidence-relative-survival-stage-diagnosis.htm.

2. Cancer Incidence, Mortality, Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019;Kocarnik;JAMA Oncol.,2022

3. Trajectories of Disability in Activities of Daily Living in Advanced Cancer or Respiratory Disease: A Systematic Review;Fettes;Disabil. Rehabil.,2022

4. Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update;Ferrell;J. Clin. Oncol.,2017

5. Models of Palliative Care Delivery for Patients With Cancer;Hui;J. Clin. Oncol.,2020