Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review

Author:

Braguês Ricardo1ORCID,Marvão Maria Francisca1,Correia Patrícia12ORCID,Silva Raquel M.12ORCID

Affiliation:

1. Universidade Católica Portuguesa, Faculty of Dental Medicine, 3504-505 Viseu, Portugal

2. Universidade Católica Portuguesa, Center for Interdisciplinary Research in Health (CIIS), 3504-505 Viseu, Portugal

Abstract

Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as cryotherapy, low-level laser therapy, and natural compounds for this condition. The aim of this systematic review was to identify and compare therapies for the management of cancer treatment-induced oral mucositis in pediatric patients. From 2655 articles obtained in initial searches, 39 articles were considered in this systematic review, after applying inclusion/exclusion criteria. Low-level laser therapy, palifermin, honey, and zinc demonstrated reductions in oral mucositis incidence, duration, severity, and pain reported by the patient. Although there are several therapies in place for the prevention and treatment of oral mucositis in children, evidence of their efficacy is still inconclusive to establish accurate clinical protocols.

Funder

Portuguese Foundation for Science and Technology

Publisher

MDPI AG

Reference71 articles.

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