A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma

Author:

Qian Jia-Yi1ORCID,Hao Yun2,Yu Hai-Hong2,Wu Lei-Lei1ORCID,Liu Zhi-Yuan2,Peng Qiao2,Li Zhi-Xin1ORCID,Li Kun1,Liu Yu’e2ORCID,Wang Rang-Rang3ORCID,Xie Dong1ORCID

Affiliation:

1. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China

2. School of Medicine, Tongji University, Shanghai 200092, China

3. Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China

Abstract

This study aimed to construct an effective nomogram based on the clinical and oxidative stress-related characteristics to predict the prognosis of stage I lung adenocarcinoma (LUAD). A retrospective study was performed on 955 eligible patients with stage I LUAD after surgery at our hospital. The relationship between systematic-oxidative-stress biomarkers and the prognosis was analyzed. The systematic oxidative stress score (SOS) was established based on three biochemical indicators, including serum creatinine (CRE), lactate dehydrogenase (LDH), and uric acid (UA). SOS was an independent prognostic factor for stage I LUADs, and the nomogram based on SOS and clinical characteristics could accurately predict the prognosis of these patients. The nomogram had a high concordance index (C-index) (0.684, 95% CI, 0.656–0.712), and the calibration curves for recurrence-free survival (RFS) probabilities showed a strong agreement between the nomogram prediction and actual observation. Additionally, the patients were divided into two groups according to the cut-off value of risk points based on the nomogram, and a significant difference in RFS was observed between the high-risk and low-risk groups (p < 0.0001). SOS is an independent prognostic indicator for stage I LUAD. These things considered, the constructed nomogram based on SOS could accurately predict the survival of those patients.

Funder

cultivation project of Huadong Hospital for National Natural Science Foundation program

Shanghai ShenKang Hospital Development Centre

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Outstanding Young Medical Talent of Rising Star in Medical Garden of Shanghai Municipal Health Commission “Dong Xie”

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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