ImmunoPET Targeting Receptor Tyrosine Kinase: Clinical Applications

Author:

Linguanti Flavia12ORCID,Abenavoli Elisabetta Maria3,Calabretta Raffaella4ORCID,Berti Valentina1ORCID,Lopci Egesta5ORCID

Affiliation:

1. Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, Italy

2. Nuclear Medicine Department, Ospedale San Donato, 52100 Arezzo, Italy

3. Nuclear Medicine Division, Careggi University Hospital, 50134 Florence, Italy

4. Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria

5. Nuclear Medicine Unit, IRCCS—Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy

Abstract

Receptor tyrosine kinases, or RTKs, are one large family of cell surface receptors involved in signal transduction, which represent an integral part of the signaling pathways. They play a crucial role in most important cellular processes, starting with the cell cycle, proliferation and differentiation, as well as cell migration, metabolism and survival. The introduction of ImmunoPET evaluating the expression of RTKs by specific monoclonal antibodies (mAbs) or antibody fragments is regarded as a promising tool for imaging treatment efficacy and developing anticancer therapeutics. Our review focuses mainly on the current clinical research regarding ImmunoPET targeting RTKs, with particular interest in the epidermal growth factor family, or HER family, and vascular endothelial-derived growth factor/receptor.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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