The Diverse Contributions of Fucose Linkages in Cancer

Author:

Keeley Tyler S.,Yang Shengyu,Lau Eric

Abstract

Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.

Funder

National Cancer Institute

Harry J. Lloyd Charitable Trust

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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