Abstract
Cancer genomes evolve in a punctuated manner during tumor evolution. Abrupt genome restructuring at key steps in this evolution has been called “genome chaos.” To answer whether widespread genome change is truly chaotic, this review (i) summarizes the limited number of cell and molecular systems that execute genome restructuring, (ii) describes the characteristic signatures of DNA changes that result from activity of those systems, and (iii) examines two cases where genome restructuring is determined to a significant degree by cell type or viral infection. The conclusion is that many restructured cancer genomes display sufficiently unchaotic signatures to identify the cellular systems responsible for major oncogenic transitions, thereby identifying possible targets for therapies to inhibit tumor progression to greater aggressiveness.
Reference187 articles.
1. Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine;Heng,2019
2. Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer
3. Characterizing the ecological and evolutionary dynamics of cancer
4. The Material Basis of Evolution, Reissued (The Silliman Memorial Lectures Series), 1982;Goldschmidt,1940
5. Evolution: A View from the 21st Century;Shapiro,2011
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献