Environmental Contaminants Modulate Breast Cancer Development and Outcome in TP53 p.R337H Carriers and Noncarriers

Author:

Gerber Viviane K. Q.,Paraizo Mariana M.,Ibañez Humberto C.ORCID,Casali-da-Rocha José C.ORCID,Pinto Emilia M.ORCID,Andrade Diancarlos P.ORCID,Ibañez Marilea V. C.,Komechen Heloisa,Figueiredo Mirna M. O.,Custódio Gislaine,Fiori Carmem M. C. M.,Balbinotti José H. G.,Nardin Jeanine M.ORCID,Almeida Thais A.,Beltrame Olair O.,Yamada Paula A.,de Fraga Gabriel S.ORCID,de Brito Lucas L.,Martins Jamylle,Melanda Viviane S.,Licht Otavio A. B.,Teixeira Victoria Z.,Pinho Sandy K. S.,Bottini SilviaORCID,Lalli Enzo,Zambetti Gerard P.ORCID,Figueiredo Bonald C.

Abstract

Two major concerns associated with cancer development in Paraná state, South Brazil, are environmental pollution and the germline TP53 p.R337H variant found in 0.27–0.30% of the population. We assessed breast cancer (BC) risk in rural (C1 and C2) and industrialized (C3) subregions, previously classified by geochemistry, agricultural productivity, and population density. C2 presents lower organochloride levels in rivers and lower agricultural outputs than C1, and lower levels of chlorine anions in rivers and lower industrial activities than C3. TP53 p.R337H status was assessed in 4658 women aged >30 years from C1, C2, and C3, subsequent to a genetic screening (Group 1, longitudinal study). BC risk in this group was 4.58 times higher among TP53 p.R337H carriers. BC prevalence and risk were significantly lower in C2 compared to that in C3. Mortality rate and risk associated with BC in women aged >30 years (n = 8181 deceased women; Group 2) were also lower in C2 than those in C3 and C1. These results suggest that environmental factors modulate BC risk and outcome in carriers and noncarriers.

Funder

Coordenação de Aperfeicoamento de Pessoal de Nível Superior

Associação Hospitalar de Proteção à Infância Dr. Raul Carneiro

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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