Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis

Author:

Raimondo Diego1ORCID,Raffone Antonio23ORCID,Virgilio Agnese12ORCID,Ferla Stefano12,Maletta Manuela12,Neola Daniele3,Travaglino Antonio4,Paradisi Roberto2ORCID,Hernández Alicia56,Spagnolo Emanuela5ORCID,García-Pineda Virginia6ORCID,Lenzi Jacopo7ORCID,Guida Maurizio3,Casadio Paolo12,Seracchioli Renato12

Affiliation:

1. Division of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy

2. Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy

3. Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy

4. Unit of Pathology, Department of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy

5. Department of Gynecology, La Paz University Hospital, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain

6. Department of Gynecologic Oncology, La Paz University Hospital, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain

7. Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy

Abstract

Adenomyosis has been associated with better survival outcomes in women with endometrial cancer. However, although the endometrial cancer patients’ risk stratification has been revolutionized by molecular findings, the impact of the molecular signature on the favorable prognosis of endometrial cancer patients with coexistent adenomyosis is unknown. The aim of our study was to compare the prevalence of molecular groups at poor and intermediate prognosis between endometrial cancer patients with and without coexistent adenomyosis. A multicentric, observational, retrospective, cohort study was performed to assess the differences in the prevalence of p53-abnormal expression (p53-abn) and mismatch repair protein-deficient expression (MMR-d) signatures between endometrial cancer patients with and without coexistent adenomyosis. A total of 147 endometrial cancer patients were included in the study: 38 in the adenomyosis group and 109 in the no adenomyosis group. A total of 37 patients showed the MMR-d signature (12 in the adenomyosis group and 25 in the no adenomyosis group), while 12 showed the p53-abn signature (3 in the adenomyosis group and 9 in the no adenomyosis group). No significant difference was found in the prevalence of p53-abn (p = 1.000) and MMR-d (p = 0.2880) signatures between endometrial cancer patients with and without coexistent adenomyosis. In conclusion, the molecular signature does not appear to explain the better prognosis associated with coexistent adenomyosis in endometrial cancer patients. Further investigation of these findings is necessary through future larger studies.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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