Cutaneous Squamous Cell Carcinoma: An Updated Review

Author:

Jiang Rina1ORCID,Fritz Mike1,Que Syril Keena T.1

Affiliation:

1. Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA

Abstract

Representing the second most common skin cancer, the incidence and disease burden of cutaneous squamous cell carcinoma (cSCC) continues to increase. Surgical excision of the primary site effectively cures the majority of cSCC cases. However, an aggressive subset of cSCC persists with clinicopathological features that are indicative of higher recurrence, metastasis, and mortality risks. Acceleration of these features is driven by a combination of genetic and environmental factors. The past several years have seen remarkable progress in shaping the treatment landscape for advanced cSCC. Risk stratification and clinical management is a top priority. This review provides an overview of the current perspectives on cSCC with a focus on staging, treatment, and maintenance strategies, along with future research directions.

Publisher

MDPI AG

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Contribution of Keratinocytes in Skin Cancer Initiation and Progression;International Journal of Molecular Sciences;2024-08-13

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