Abstract
Hepatocellular carcinoma (HCC) remains a global health challenge, causing 600,000 deaths each year. Infectious factors, including hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV), have long been considered the major risk factors for the development and progression of HCC. These pathogens induce hepatocyte transformation through a variety of mechanisms, including insertional mutations caused by viral gene integration, epigenetic changes, and the induction of long-term immune dysfunction. The discovery of these mechanisms, while advancing our understanding of the disease, also provides targets for new diagnostic and therapeutic approaches. In addition, the discovery and research of chronic HEV infection over the past decade indicate that this common hepatitis virus also seems to have the potential to induce HCC. In this review, we provide an overview of recent studies on the link between hepatitis virus and HCC, as well as new diagnostic and therapeutic approaches to HCC based on these findings. Finally, we also discuss the potential relationship between HEV and HCC. In conclusion, these associations will further optimize the diagnosis and treatment of infection-associated HCC and call for better management policies.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Post-Doctor Research Project, West China Hospital, Sichuan University
Key R&D Program of Sichuan Provincial Department of Science and Technology
Sichuan University postdoctoral interdisciplinary Innovation Fund
Reference137 articles.
1. A global view of hepatocellular carcinoma: Trends, risk, prevention and management;Yang;Nat. Rev. Gastroenterol. Hepatol.,2019
2. Hepatocellular carcinoma;Llovet;Nat. Rev. Dis. Primers,2021
3. Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy;Dhanasekaran;Gastroenterology,2019
4. Ninio, L., Nissani, A., Meirson, T., Domovitz, T., Genna, A., Twafra, S., Srikanth, K.D., Dabour, R., Avraham, E., and Davidovich, A. (2019). Hepatitis C Virus Enhances the Invasiveness of Hepatocellular Carcinoma via EGFR-Mediated Invadopodia Formation and Activation. Cells, 8.
5. Epidemiological and etiological variations in hepatocellular carcinoma;Sagnelli;Infection,2020
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