Lymphomas of the Vulva: A Review of the MITO Rare Cancer Group

Author:

Magazzino Francescapaola1ORCID,Aristei Cynthia2ORCID,Passarelli Anna3,Pierini Antonio4,De Giorgi Ugo5ORCID,Martinello Ruby6ORCID,Domenici Lavinia7,Pignata Sandro3ORCID,Mangili Giorgia8ORCID,Cormio Gennaro910ORCID

Affiliation:

1. Complex Operating Unit Obstetrics and Gynaecology, Ospedale Civile di San Donà di Piave-Venezia, AULSS4 Veneto Orientale, 30027 San Donà di Piave, Italy

2. Radiation Oncology Section, Department of Medicine and Surgery, Perugia General Hospital Sant’Andrea delle Fratte, University of Perugia, 06156 Perugia, Italy

3. Department of Urology and Gynecology, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, 80144 Napoli, Italy

4. Division of Hematolgy and Clinical Immunolgy, Department of Medicine and Surgery, University of Perugia, 06156 Perugia, Italy

5. Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, 47014 Meldola, Italy

6. Department of Medical Sciences, Institute of Obstetrics and Gynecology, University of Ferrara, 44121 Ferrara, Italy

7. 2nd Division of Obstetrics and Gynaecology, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56126 Pisa, Italy

8. Department of Obstetrics and Gynaecology, San Raffaele Scientific Institute, 20132 Milano, Italy

9. Gynecologic Oncoly Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy

10. Department of Interdisciplinary Medicine, University of Bari, 70124 Bari, Italy

Abstract

Since they are very rare tumors, lymphomas of the vulva are often not properly recognized. Patients with vulvar lymphoma are generally elderly and the classical manifestation of the disease is a vulvar mass. No significant age differences have been found between primary and secondary lymphoma. To make a correct diagnosis, it is therefore necessary to use not only histological examination but also the genetic and molecular profile in order to establish optimal therapeutic management. Literature analysis confirm the good prognosis of this disease.

Publisher

MDPI AG

Reference79 articles.

1. Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., and Vardiman, J.W. (2008). World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, IARC. [4th ed.].

2. Swerdlow, S.H., World Health Organization, and International Agency for Research on Cancer (2017). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, IARC. [4th ed.].

3. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group;Harris;Blood,1994

4. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms;Alaggio;Leukemia,2022

5. Lymphoma;Mugnaini;Prim. Care,2016

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