MitoTam-01 Trial: Mitochondrial Targeting as Plausible Approach to Cancer Therapy. Comment on Yap et al. Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors and Acute Myeloid Leukemia: Phase I Trials. Nat. Med. 2023, 29, 115

MitoTam-01 Trial: Mitochondrial Targeting as Plausible Approach to Cancer Therapy. Comment on Yap et al. Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors and Acute Myeloid Leukemia: Phase I Trials. Nat. Med. 2023, 29, 115–126

Published:2023-09-08 Issue:18 Volume:15 Page:4476
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Neuzil Jiri¹²³⁴^ORCID,Rohlena Jakub²^ORCID,Werner Lukas²,Bielcikova Zuzana⁴⁵^ORCID

Affiliation:

1. School of Pharmacy and Medical Science, Griffith University, Southport, Qld 4222, Australia

2. Institute of Biotechnology, Czech Academy of Sciences, 252 50 Prague, Czech Republic

3. Faculty of Science, Charles University, 128 00 Prague, Czech Republic

4. First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic

5. General University Hospital, Charles University, 128 08 Prague, Czech Republic

Abstract

A recent paper published in Nature Medicine reported on the Phase I clinical trial of a mitochondria-targeting anti-cancer agent IACS-01059 in patients with acute myeloid leukemia (AML) and solid tumors [...]

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/18/4476/pdf

Reference18 articles.

1. Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: Phase I trials;Yap;Nat. Med.,2023

2. Biological and metabolic effects of IACS-010759, an OxPhos inhibitor, on chronic lymphocytic leukemia cells;Vangapandu;Oncotarget,2018

3. IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism;Tsuji;J Biol Chem.,2020

4. Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma;Bajpai;Nat. Commun.,2020

5. Combination treatment with radiotherapy and a novel oxidative phosphorylation inhibitor overcomes PD-1 resistance and enhances antitumor immunity;Chen;J. Immunother. Cancer,2020

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