The Role of Non-Coding RNAs in Myelodysplastic Neoplasms-Reference-Cited by-同舟云学术

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Published:2023-09-30 Issue:19 Volume:15 Page:4810
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Georgoulis Vasileios¹^ORCID,Koumpis Epameinondas¹,Hatzimichael Eleftheria¹²^ORCID

Affiliation:

1. Department of Haematology, University Hospital of Ioannina, Faculty of Medicine, University of Ioannina, 45 500 Ioannina, Greece

2. Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19 107, USA

Abstract

Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/19/4810/pdf

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