Affiliation:
1. Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, ul. Mickiewicza 52, 60-834 Poznań, Poland
Abstract
Diabetes mellitus is a significant health problem for medicine and economics. In 80–90% of cases, it is type 2 diabetes (T2DM). An essential aspect for people with T2DM is to control blood glucose levels and avoid significant deviations. Modifiable and non-modifiable factors influence the incidence of hyperglycemia and, sometimes, hypoglycemia. The lifestyle modifiable factors are body mass, smoking, physical activity, and diet. These affect the level of glycemia and impact molecular changes. Molecular changes affect the cell’s primary function, and understanding them will improve our understanding of T2DM. These changes may become a therapeutic target for future therapy of type 2 diabetes, contributing to increasing the effectiveness of treatment. In addition, the influence of external factors (e.g., activity, diet) on each domain of molecular characterization has gained importance towards a better understanding of their role in prevention. In the current review, we aimed to collect scientific reports on the latest research about modifiable factors connected with the style of life which affect the glycemic level in the context of molecular discoveries.
Subject
Microbiology (medical),Molecular Biology,General Medicine,Microbiology
Reference119 articles.
1. World Health Organisation (2022, May 28). Diabetes-Key Facts. Available online: https://www.who.int/news-room/fact-sheets/detail/diabetes.
2. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition;Saeedi;Diabetes Res. Clin. Pract.,2019
3. Polskie Towarzystwo Diabetologiczne (2022, May 28). Guidelines on the Managment of Diabetic Patients. Available online: https://cukrzyca.info.pl/zalecenia_kliniczne/2020_guidelines_on_the_management_of_diabetic_patients.
4. 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2021;Association;Diabetes Care,2021
5. Pathophysiology of Diabetes Mellitus;Guthrie;Crit. Care Nurs. Q.,2004